Large-scale whole genome sequencing (WGS) studies promise to revolutionize cancer research by identifying targets for therapy and by discovering molecular biomarkers to aid early diagnosis, to better determine prognosis and to improve treatment response prediction. Such projects raise a number of ethical, legal, and social (ELS) issues that should be considered. In this study, we set out to discover how these issues are being handled across different jurisdictions.

Sustained attention, a key cognitive skill that improves during childhood and adolescence, tends to be worse in some emotional and behavioural disorders. Sustained attention is typically studied in non-affective task contexts; here, we used a novel task to index performance in affective versus neutral contexts across adolescence (N = 465; ages 11–18). We asked whether: (i) performance would be worse in negative versus neutral task contexts; (ii) performance would improve with age; (iii) affective interference would be greater in younger adolescents; (...) (iv) adolescents at risk for depression and higher in anxiety would show overall worse performance; and (v) would show differential performance in negative contexts. Results indicated that participants performed more poorly in negative contexts and showed age-related performance improvements. Those at risk of depression performed more poorly than those at lower risk. However, there was no difference between groups as a result of affective context. For anxiety there was no difference in performance as a function of severity. However, those with higher anxiety showed less variance in their reaction times to negative stimuli than those with lower anxiety. One interpretation is that moderate levels of emotional arousal associated with anxiety make individuals less susceptible to the distracting effects of negative stimuli. (shrink)

In Natural Ethical Facts William Casebeer argues that we can articulate a fully naturalized ethical theory using concepts from evolutionary biology and cognitive science, and that we can study moral cognition just as we study other forms of cognition. His goal is to show that we have "softly fixed" human natures, that these natures are evolved, and that our lives go well or badly depending on how we satisfy the functional demands of these natures. Natural Ethical Facts is a (...) comprehensive examination of what a plausible moral science would look like.Casebeer begins by discussing the nature of ethics and the possible relationship between science and ethics. He then addresses David Hume's naturalistic fallacy and G. E. Moore's open-question argument, drawing on the work of John Dewey and W. V. O. Quine. He then proposes a functional account of ethics, offering corresponding biological and moral descriptions. Discussing in detail the neural correlates of moral cognition, he argues that neural networks can be used to model ethical function. He then discusses the impact his views of moral epistemology and ontology will have on traditional ethical theory and moral education, concluding that there is room for other moral theories as long as they take into consideration the functional aspect of ethics; the pragmatic neo-Aristotelian virtue theory he proposes thus serves as a moral "big tent." Finally, he addresses objections to ethical naturalism that may arise, and calls for a reconciliation of the sciences and the humanities. "Living well," Casebeer writes, "depends upon reweaving our ethical theories into the warp and woof of our scientific heritage, attending to the myriad consequences such a project will have for the way we live our lives and the manner in which we structure our collective moral institutions.". (shrink)

In lieu of an abstract, here is a brief excerpt of the content:What Do You Mean, Rhetoric Is Epistemic?William D. HarpineIn 1967, Robert L. Scott (1967) advocated that "rhetoric is epistemic." This concept has enriched the work of rhetorical theorists and critics. Scott's essay is founded in a concept of argumentative justification in rhetoric, viewed as an alternative to analytic logic. Other writers, including Brummett (1976), Railsback (1983), and Cherwitz and Hikins (1986), have offered variations on Scott's theme. The (...) thesis that rhetoric is epistemic has been controversial, however, and from the tone of the debate one may draw two conclusions: many rhetorical theorists feel that Scott was on to something important, and the thesis as it has been developed is flawed. Much of the dispute centers on what the thesis means. These discussions have not yet adequately clarified that issue.The philosopher's most fundamental obligation is to define terms with care. It is in precisely this respect that the rhetoric-is-epistemic theorists have fallen short. Some of the key terms in this literature include rhetoric, knowledge, certainty, and truth. In too many cases, the writers on rhetorical epistemology have not defined their key terms at all. In other cases, their definitions are inadequate or inconsistent. This essay undertakes to sort out the most important definitional problems, which center on the rhetoric-is-epistemic theorists' habit of equivocating about the meanings of "rhetoric" and "certainty." The result makes it possible to endorse the validity of Scott's essentially ethical conclusions, while dismissing a number of unnecessary complexities in the arguments made by rhetoric-as-epistemic theorists. Finally, a few alternatives that might lead to more robust foundations for the rhetoric-as-epistemic thesis are suggested.In 1978, after reviewing four distinct interpretations of the claim that rhetoric is epistemic, Leff concluded that clarification of what that claim means "deserves more disciplined treatment than it has received in the recent literature" (1978, 77). The same could still be said. After some [End Page 335] thirty years of active research and speculation on the topic, one now sees fewer publications specifically advocating that rhetoric is epistemic. The distinguished rhetorical theorist Barry Brummett (1990) has declared the thesis deceased (69-72).All the same, textbook authors treat the thesis as a given, despite their tendency to interpret it in wildly different ways. Foss, for example, puts forward a view that "in the field of communication, the idea that rhetoric creates reality is known as the notion that rhetoric is epistemic, which simply means that rhetoric creates knowledge; epistemology is the study of the origin and nature of knowledge" (1989, 122; emphasis in the original). This version of the thesis, claiming that rhetoric actually "creates reality," might be more ontological than it is epistemic.1 Herrick takes a dialectical view that "through rhetorical interaction, people come to accept some ideas as true and to reject others as false. Thus, rhetoric's epistemic function in society can be seen in some ways to be a result of its benefit of testing ideas." Herrick continues that "once an idea has been tested thoroughly by a group, community, and society, it becomes part of what these groups take to be knowledge." Herrick contrasts this with the rejected view that "knowledge is all objective in nature and comes to us by way of direct experience or education" (1997, 22). Both Herrick and Foss offer interesting theses, and both attribute their views to Scott, but their views are obviously very different. There can be no surer evidence of the failure to use terms precisely.Brummett (1990) attributes the demise of rhetoric-is-epistemic research to the failure of critics to employ the idea in rhetorical criticism. Brummett might be right to the extent that much of the rhetoric-is-epistemic literature is indeed exceptionally abstract. Specific discussions might clarify some issues. Nonetheless, some notable rhetorical critics have indeed employed a concept that rhetoric is epistemic (e.g., Scott and Klumpp 1984; Sullivan 1992). The issues remain unclear. Furthermore, rhetorical criticism per se cannot clarify the meanings of theoretical terms. More likely, one sees less and less published research about the thesis that rhetoric is epistemic precisely because the thesis has not been laid out clearly... (shrink)

Early in Being and Time Heidegger announces that the primary concept by means of which he aims to understand Dasein is the concept to which he gives the name ‘existence.’ But what is existence? Existence is, roughly, that feature of Dasein that its self-understanding is constitutive of its being what or who it is. In an important sense, this concept embodies Heidegger’s existentialism. At the center of existentialism lies the claim that humans are given their content neither by an ahistorical, (...) transcultural essence, nor by nature. Rather, Dasein itself determines this content in its act of self-understanding. Kierkegaard expressed this in his famous formulation that “The self is that which relates itself to itself;” Ortega in his catchy phrase, “Man has no nature;” and Sartre in his notorious proposition, “Existence comes before essence.” All of these dicta articulate the same idea. (shrink)

The developing neuromuscular junction has provided an important paradigm for studying synapse formation. An outstanding feature of neuromuscular differentiation is the aggregation of acetylcholine receptors (AChRs) at high density in the postsynaptic membrane. While AChR aggregation is generally believed to be induced by the nerve, the mechanisms underlying aggregation remain to be clarified. A 43‐kD protein (43k) normally associated with the cytoplasmic aspect of AChR clusters has long been suspected of immobilizing AChRs by linking them to the cytoskeleton. In recent (...) studies, the AChR clustering activity of 43k has, at last, been demonstrated by expressing recombinant AChR and 43k in non‐muscle cells. Mutagenesis of 43k has revealed distinct domains within the primary structure which may be responsible for plasma membrane targeting and AChR binding. Other lines of study have provided clues as to how nerve‐derived (extracellular) AChR‐cluster inducing factors such as agrin might activate 43k‐driven postsynaptic membrane specialization. (shrink)

In the rod‐shaped cells of E. coli, chromosome segregation takes place immediately after replication has been completed. A septum then forms between the two sister chromosomes. In the absence of certain membrane proteins, cells grow instead as large, multichromosomal spheres that divide successively in planes that are at right angles to one another. Although multichromosomal, the spherical cells cannot be maintained as heterozygotes. These observations imply that, in these mutants, each individual chromosome gives rise to a separate clone of descendant (...) cells. This suggests a model in which sites for cell division form between pairs of sister chromosomes at the time of segregation, but are not used in spherical cells until further rounds of replication have taken place, thus ensuring clonal (‘hierarchical’) segregation of chromosomes into progeny cells. The role of the morphogenetic membrane proteins is to convert the basically spherical cell into a cylinder that is able to divide as soon as replication and segregation have been completed, and thus to maximise the number of viable cells per genome. (shrink)

Both the Sarbanes–Oxley Act of 2002 and the Dodd-Frank Act of 2010 include clawback provisions that require executives to pay back incentive compensation earned on financial statements that are restated in a subsequent period. Such provisions intend to reduce unethical reporting behavior by executives who otherwise might be more inclined to misstate financial statements to boost incentive-based compensation. However, such provisions could promote rather than deter unethical behavior. In particular, Pyzoha :2515–2536, 2015) finds that, under certain conditions, executives are less (...) willing to restate financial statements in the presence of a clawback policy. Similarly, auditors might also act unethically by being less likely to propose restatements in the presence of clawbacks to avoid upsetting management. To examine this possibility, this study reports the results of three experiments that examine the effect of clawback provisions on auditor judgment. Contrary to expectations, our three experiments, along with supplemental qualitative evidence consistently indicate that clawbacks do not affect auditors’ propensity to propose restatements. These results suggest that a decrease in the number of restatements in a clawback environment will not be due to auditors acting unethically to appease management. The effects of clawbacks on auditors’ risk assessments, however, are less conclusive. As such, we offer potential post hoc explanations to guide future research. (shrink)

This article reviews the effects of malnutrition on early brain development using data generated from animal experiments and human clinical studies. Three related processes, each with their own functional consequences, are implicated in the alteration of brain development. (1) Maternal undernutrition at the start of pregnancy results in reduced transfer of nutrients across the placenta, allowing the conservation of effort for future reproductive episodes. (2) Differential allocation to growing organs by the fetus in response to nutritional stress spares the brain (...) to a large though still limited degree, reflecting the organ’s relative contribution to survival and reproductive success. (3) Prenatal malnutrition disrupts developing neurotransmitter systems, which results in the expression of specific cognitive and affective traits. It is argued that the increasing size and therefore cost of the brain, in conjunction with increasing ecological instability and marginality, reinforced selection for maternally controlled growth suppression of offspring, reallocation of organ growth rates by offspring, and behavioral changes related to development of neurotransmitter systems. (shrink)

Michael Zbaraschuk’s recent article, “Not Radical Enough: William Dean’s Problems with God and History,”1 deserves a published response, because it applies not only to my work but to that of many other philosophical theologians, some of whom read this journal. Before discussing the larger issues, I must attend to an item of scholarly housekeeping. Although Zbaraschuk draws narrowly, i.e., from only two of my books—History Making History (1988) and The Religious Critic in American Culture (1994)—he applies his arguments indiscriminately (...) to my work as a totality, omitting most crucially the score of articles and the book written between 1994 and the present. Of course, there is nothing wrong with an .. (shrink)

To date, there have been only two scholarly papers devoted to a comparison of Gestalt psychology with the psychology of William James. An early paper by Mary Whiton Calkins called attention to numerous similarities between these two schools of thought. However, a more recent paper by Mary Henle argues that the ideas of William James, as presented in The Principles of Psychology, are irrelevant to Gestalt psychology. In what follows, this claim is evaluated both in terms of The (...) Principles and Jamesís larger vision as set forth in his mature philosophical works. Although there are important differences between James and the Gestalt psychologists, there are also striking similarities particularly when the two schools are examined in the light of Jamesís mature philosophical perspectives. (shrink)

A central theme to be found in Dewey’s writings is his criticism of theories of knowledge proposed throughout the history of Western philosophy. None of the once familiar “isms,” whether it be a variant of empiricism, rationalism, or idealism, escaped Dewey’s scrutiny. And each in its turn proved to be unacceptable to Dewey, because it was found that each rested upon what Dewey referred to as “the philosophical fallacy,” namely “the conversion of eventual functions into antecedent existence,” or the fallacy (...) of selective emphasis. Basically, this fallacy amounted for Dewey to the emphasis of one aspect of scientific inquiry to the exclusion of the rest, and taking the features characteristic of that aspect as paradigmatic for the purpose of accounting for knowledge. Thus, for example, advocates of what Dewey called sensationalism, for whom knowledge was to be explicated in terms of an immediate acquaintance with a perceptual given, emphasized an aspect of scientific inquiry, viz., that inquiry is engaged in only when some given situation is problematic, without regard to the fact that even those features of a problematic situation, which are taken to be given and stable features for purposes of resolving the problem, are so taken only provisionally, depending upon whether the ensuing inquiry is successful in resolving the problem at hand. (shrink)

This paper is a review of the influence that lógos has had on ancient Greek, Jewish, and Christian writings. During the philosophical era known as Middle Platonism, the concept/ontology of the lógos played a unique role in enabling Pagan, Jewish, and Christian intellectuals to communicate on a small space of common ground.

This collection of essays is concerned with Paul de Man's work as a literary theorist, particularly his later, linguistically-informed contribution to the reading and interpretation of literature. The essays in this collection argue that de Man's legacy is complex and multidimensional. Paul de Man's work in "deconstructive" literary criticism is examined in some detail with regard to its continuing pertinence to recent developments in literary study. This collection argues persuasively that de Man's work continues to be important to the so-called (...) "afterlife" of theory. (shrink)

This book is a systematic reconstruction of Heidegger's account of time and temporality in Being and Time. The author locates Heidegger in a tradition of 'temporal idealism' with its sources in Plotinus, Leibniz, and Kant. For Heidegger, time can only be explained in terms of 'originary temporality', a concept integral to his ontology. Blattner sets out not only the foundations of Heidegger's ontology, but also his phenomenology of the experience of time. Focusing on a neglected but central aspect of Being (...) and Time, this book will be of considerable interest to all students of Heidegger both inside and outside philosophy. (shrink)

Physiological studies show that the driving force for long distance transport and the control of nutrient movement in plants resides largely in the regulated, membrane transport of a few carbohydrates, principally sucrose. The evidence is reviewed here and biochemical studies on sucrose carrier proteins are discussed.

Zu seinen Lebzeiten war Kurt Gödel außerhalb der Fachwelt der Mathematiker, Philosophen und theoretischen Physiker kaum bekannt. Zu Beginn seiner Karriere schuf er beeindruckende Arbeiten zur Vollständigkeit und Beweisbarkeit formaler logischer Systeme, die zu seiner Dissertation und seiner Habilitations-schrift wurden und ihn unter Fachleuten weltberühmt machten. Seine Unvoll-ständigkeitssätze läuteten das Ende der formal-logischen Programme der Logizisten (Russell et al.) und der Formalisten (Hilbert et al.) ein. Später erzielte er auch signifikante Ergebnisse in der Mengenlehre. Nach seiner Emigration in die USA (...) (Princeton), widmete er sich mehr der Philosophie, dem Leitmotiv seines Lebens, und er fand auch eine einzigartige Lösung zu Einsteins Feld-gleichungen der Gravitation, sein "Gödel-Universum". Dieses Buch beschreibt sowohl den Gödel, der ein genialer Wissenschaftler war, und der gewagte und neuartige Hypothesen zu den Fundamenten der Mathe-matik und Physik hervorbrachte, ‒ als auch den Gödel, der ein perfekter Rationalist war, aber sein Alltagsleben nur mit Mühe meistern konnte und zeitlebens unter Depressionen, Angstneurosen und Hypochondrie litt. Ein Leben voller Paradoxen, in dem er trotz all seiner psychischen Probleme Beachtliches leistete und zu einem Vorbild für viele jüngere Wissenschaftler wurde. Das Buch liefert den Kontext zu seinen Errungenschaften, die ein verblüffend breites Spektrum intellektueller Unternehmungen darstellen, und zu seiner zunehmenden Geisteskrankheit; und es zeigt, wie er eine lange und erfolgreiche Karriere mit Hilfe seiner loyalen Ehefrau Adele und einigen seiner Freunde durchlaufen konnte. Dies ist eine faszinierende Geschichte der wissen-schaftlichen Genialität und der menschlichen Natur. (shrink)

The American Journal of Bioethics, Volume 12, Issue 7, Page 42-43, July 2012.

Volume 24, Issue 7-8, November - December 2019, Page 871-872.

Contemporary U.S. policy makers often characterize the U.S. counterinsurgency experience in El Salvador as a successful model to be followed in other contexts. This article argues that these characterizations significantly overstate the positive lessons of El Salvador, and ignore important cautionary implications. During the first part of the conflict, neither the Armed Forces of El Salvador nor the U.S. followed the tenets of counterinsurgency doctrine. The FAES killed tens of thousands of non-combatants in 1979 and 1980, before the civil war (...) even began. This repression may have preempted an incipient popular insurrection, but it also locked in a determined social base that enabled the armed left to build a highly effective and sustained insurgency. In 1984, the U.S. had to save the FAES from likely defeat through a major increase in military aid, especially airpower. When the Farabundo Martí National Liberation Front switched to a classical guerrilla strategy, the FAES, despite considerable U.S. aid, seldom followed best practices in counterinsurgency. Democratization and redistributional reforms were partial and flawed in implementation. The war settled into a stalemate that would likely have continued indefinitely had it not been for the collapse of the socialist bloc and significant changes in the interests of Salvadoran elites that were largely incidental to U.S. policies.The most important cautionary lesson is that indiscriminate violence against civilians early in a conflict can create dynamics that are very difficult to overcome in subsequent stages. (shrink)

The normative relationship between text and sermon is one of mutuality in which the preacher creates an interplay between the agenda of the text and the agenda of the congregation.